“Life is about growing old and feeling young.”
contributed by: Rudy InabaDirector of Clinical Relations & Corporate Development
While chronological age counts the number of years you’ve been alive, biological age tells a more comprehensive story about your health. It assesses speciﬁc physiological measures to establish an individual’s wellness relative to their chronological age. For example, a healthy individual in their 40s may have a lower biological age than someone of poorer health in their 30s, despite having a higher chronological age. In other words, biological age tells us how well our bodies are functioning – and how likely we are to develop age-related conditions – based on key biomarkers.
Researchers have looked at many factors when attempting to come up with a widely-accepted measurement for biological age. Some believe that it should be measured based on molecular markers of inﬂammation, including C-reactive protein.  Others feel biological age encompasses mortality, the ability to function, and the need for therapies and interventions to extend health (or lack thereof).  Others still feel that biological age is marked by bodily changes which take place, including persistent, low-grade inﬂammation despite a lack of any known pathogens, dysfunction at the cellular level, stem cells’ impeded ability to repair tissue, and cells’ decreasing ability to proliferate. 
Most recently, Yale School of Medicine researcher, Morgan Levine, PhD, and her team have come up with nine biomarkers which appear to have the greatest impact on lifespan, including:
When plugged into an advanced algorithm, these metrics yield a biological age reading which acts as a “highly robust predictor of both morbidity and mortality outcomes.” It does more than just tell you the rate at which you’re aging, however; it can also determine the therapies and lifestyle interventions that can be introduced now to lower your risk for serious diseases such as cardiovascular disease and coronary heart disease. As a result, understanding your biological age can pave the way for not only a longer lifespan, but also an extension of the health span, which translates to an improved quality of life at every age. 
As leaders in age management, Cenegenics has closely looked at biological aging for the past 23 years. One of our physicians has authored the textbook used to teach physicians Age Management; in fact, we pioneered the concept as a medical specialty. We therefore ﬁrmly support Yale Medical School’s standpoint that there’s plenty you can do to take control of your biological age. Here are just a few ways we can help you reduce the rate at which you’re aging.
Many experts agree that chronic inﬂammation is a characteristic of a higher biological age. In people who are obese, fat tissue acts as an active endocrine organ, contributing to the production of TNF-alpha proteins, a biomarker of low-grade, systemic inﬂammation. This inﬂammation appears to explain the link between obesity and many co-morbidities, including:
Fortunately, Cenegenics helps patients lose weight if needed and maintain a healthy weight over the long term. We analyze speciﬁc biomarkers and perform in-depth body composition analyses, understanding that health is about more than just one number. We then provide tailored recommendations to help our patients control their weight. With this highly scientiﬁc approach to work toward getting your body perfectly tuned at the cellular level, we prompt ideal function and thus improve biological age.
Sleep deprivation, too, is linked to inﬂammation which could increase biological age. In studies, individuals whose sleep was restricted by 25 to 50% of a normal eight-hour cycle experienced inﬂammatory cytokines, which are directly linked to an elevated risk for metabolic syndrome.  The prevalence of metabolic syndrome increases with chronological age, but it’s also linked to increased biological age as well. It bears a strong link with an increased risk of diabetes, cardiovascular disease, and all-cause mortality. 
Promoting quality sleep is one of the pillars of the Cenegenics program. We believe that sleep is important at every age, and supports not only optimal physical health, but also strong brain function and emotional wellness.
Sleep deprivation can affect the body’s insulin response, increase the risk of obesity, and impede immune system functionality.  This is critical, considering the fact that some experts believe immune system changes have a direct role in the pace of biological aging.  Fortunately, the Cenegenics team helps patients develop targeted sleep management strategies to improve both the duration and quality of their slumber.
To some degree, genetics are also believed to play a role in the rate of biological aging. After all, some people are naturally predisposed to certain conditions based on hereditary factors. While we can’t change our genetic proﬁle, we can arm ourselves with as much knowledge as possible about genetic factors and make strategic choices to support the best possible outcomes with these factors in mind.
For instance, Cenegenics offers genetic testing options which can assess for everything from Alzheimer’s risk to food sensitivities. Our clinicians can then prescribe lifestyle modiﬁcations that can help to control your risk of developing serious conditions and give you the power to take a comprehensive, preventive approach against disease.
Hormone health is also related to biological age. At Cenegenics, we employ strategies to help patients achieve optimal hormone levels, reversing the biological age by rebalancing the body to where it was in their 20s and 30s. While the aging process is complex and still being studied, we know that many of the changes that take place in the body are inﬂuenced by declining hormone levels.
Fortunately, minimizing the risk of disease, frailty, and disability is possible through healthy lifestyle practices that promote hormone optimization, including:
When clinically indicated, our physicians can also recommend hormone replacement therapy options to pursue hormone balance and improved overall health in speciﬁc populations.
It isn’t a coincidence that these very factors are the pillars of the Cenegenics program. Not only do our experts take a research-based approach to help our patients reach and maintain a healthy weight, improve their sleep quality, and optimize their health in many other important ways, but we also look at each individual’s biomarkers for a better understanding of their biological age. In doing so, we tailor recommendations to your precise needs, allowing you to feel your best both now and at every age.
Although it’s impossible to turn back the chronological clock, Cenegenics can give you the tools to take control of your biological age, and thus the future. By promoting improved health across a number of key areas, including sleep, diet, and lifestyle habits, our clinicians help patients make wiser, future-focused health decisions that help them feel better both now and years down the road.
All of this is included in the Cenegenics cost of program membership, along with the many other beneﬁts that come with being one of our patients. But don’t take our word for it – see what other satisﬁed patients have to say on our Cenegenics reviews page. As you’ll see, most patients begin to feel dramatically better within 30 to 60 days on the program. We’re also the doctors who other doctors trust, with physicians and their families making up 25% of our patient population. Once you’re ready to start taking control of your biological age, contact your nearest location for more information.
 Overview of the Immune System. National Institute of Allergy and Infectious Diseases. Derived from: https://www.niaid.nih.gov/research/immune-system-overview
 See above. Derived from: https://www.niaid.nih.gov/research/immune-system-overview
 The Many Causes Of Immune Deﬁciency. German Society for Immunology. Derived from: https://www.sciencedaily.com/releases/2009/09/090914111540.htm
 Immune System Disorders. University of Rochester Medical Center Rochester, NY. Derived from: https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentID=123&ContentTypeID=134
 What Is Inﬂammation? Szalay, Jessie. LiveScience. Derived from: https://www.livescience.com/52344-inﬂammation.html
 How to boost your immune system. Harvard Medical School. Derived from: https://www.health.harvard.edu/staying-healthy/how-to-boost-your-immune-system
 Sedentary Behavior and Adiposity-Associated Inﬂammation The Multi-Ethnic Study of Atherosclerosis. A. Allison, Matthew MD, MPH, Jensky, Nicole E. PhD, Marshall, Simon J., PhD, Bertoni, Alain G. , MD, MPH, and Cushman, Mary MD. National Institute of Medicine. Derived from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244676/
 9 Surprising Ways You’re Weakening Your Immune System. Dallas, Mary Elizabeth and Marcellin, Lindsey MD, MPH. Everyday Health. Derived from: https://www.everydayhealth.com/news/9-surprising-ways-youre-weakening-your-immune-system/
 See above. Derived from: https://www.everydayhealth.com/news/9-surprising-ways-youre-weakening-your-immune-system/
 Sleep deprivation effect on the immune system mirrors physical stress. National Sleep Foundation. Derived from: https://www.sleepfoundation.org/articles/sleep-deprivation-effect-immune-system-mirrors-physical-stress
 The immune system and overtraining in athletes: clinical implications. AC Hackney and Koltun KJ. National Institute of Health. Derived from: https://www.ncbi.nlm.nih.gov/pubmed/23540172
 Evaluation of immune response after moderate and overtraining exercise in wistar rat. Zahra Gholamnezhad, Abolfazl Khajavi Rad, Mohammad Hossein Boskabady, Mahmoud Hosseini, and Mojtaba Sankian. National Institutes of Health Derived from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938879/
We will call you in a few minutes to ask some follow-up questions and share additional details about the Cenegenics program.