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What is PE 22-28? Benefits, mechanism, and uses for depression

PE 22-28 is a synthetic derivative of Spadin, an endogenous peptide that specifically blocks the TREK-1 potassium channel, a recently identified target for treating depression. PE 22-28 has been shown to induce neurogenesis after just four days, substantially faster than conventional antidepressant medications, and to stimulate synaptogenesis with fewer side…

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