What is PE 22-28? Benefits, mechanism, and uses for depression

PE 22-28 is a synthetic derivative of Spadin, an endogenous peptide that specifically blocks the TREK-1 potassium channel, a recently identified target for treating depression. PE 22-28 has been shown to induce neurogenesis after just four days, substantially faster than conventional antidepressant medications, and to stimulate synaptogenesis with fewer side…
What is Methylene blue? Benefits, mechanism, and uses for brain health

Methylene blue is a synthetic compound with anti-inflammatory, antioxidant, and mitochondrial-enhancing properties. It has been shown to boost mitochondrial energy production, support neurotransmitters involved in arousal, attention, memory, and motivation, and demonstrate promise in treating neurological disorders including mild cognitive impairment, Alzheimer’s, and Parkinson’s disease. What is Methylene blue? Methylene…
What is FGL (Fibroblast growth loop)? Benefits, mechanism, and uses

FGL (Fibroblast Growth Loop) is a small peptide derived from the neural cell adhesion molecule (NCAM), a glycoprotein found on the surface of neurons and glial cells. By stimulating the formation of new neuronal projections and synaptic connections, FGL enhances synaptic plasticity, supports memory encoding, and provides neuroprotective benefits relevant…
Cognitive Performance After 40: A 2026 Guide

Cognitive decline does not announce itself with a single event. It arrives incrementally, often mistaken for stress, poor sleep, or simply “getting older.” Cenegenics physicians observe this pattern across centers: patients notice slower recall, diminished focus, or difficulty maintaining the mental stamina their careers demand. The question is not whether cognitive…
Alzheimer’s Prevention: Understanding & Acting on Key Risk Factors

Currently, there are 5.8 million individuals in the U.S. living with Alzheimer’s. This disease and other forms of dementia take the lives of one in three seniors – more