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Hormone Optimization Done Right: Why Physician Oversight Matters More Than Ever

Hormone Optimization Done Right

January 15, 2026 - 8 Min Read

Dr. Bob Ledda

Dr. Bob Ledda

M.D., Cenegenics Physician Partner

Hormone Optimization

Before I ever heard of Cenegenics, I thought I understood health.

I grew up as a lifelong athlete. I started lifting weights at twelve, played baseball as my main sport, and cared deeply about how I looked and how I performed. I often joke that I inherited the “vanity gene,” and I am grateful I did, because wanting to be strong and lean kept me training consistently for decades. That commitment to resistance training has unquestionably protected my health as I’ve aged.

I also became a physician. I trained in emergency medicine, took care of critically ill patients, and eventually served as a director of EMS services. My life was full. I ran a fishing lodge in Alaska, flew a Beaver into the wilderness, practiced full-time in the ER, managed EMS, and raised five children. From the outside, it was a dream life. From the inside, I started to feel the slow erosion that many high-performing men feel but cannot explain.

My energy wasn’t the same. My drive and zest for life were softer around the edges. I was still “doing it all,” but it felt harder. I accepted it as aging.

Then one day, a 47-year-old man came into my emergency department with a heart attack. He was my age. He looked like me: not morbidly obese, just a little heavier in the midsection than he probably wanted to be. He did not carry the classic risk factors we are taught to look for. Yet there he was, in the middle of a myocardial infarction. I thrombolyzed him, stabilized him, and sent him on. He survived that day, but the encounter stayed with me.

I remember looking at him and thinking, “This man is my mirror.” If he can have a heart attack at 47, under our current system, what does that say about the way we identify risk? Why are we diagnosing the most common cause of death at the moment of the first event? Why is the first sign of cardiovascular disease a heart attack?

That moment laid the groundwork for a fundamental shift. It pushed me toward age-management medicine and ultimately to Cenegenics.

 

Discovering How Much Hormones Actually Matter

When I went through Cenegenics training in January 2014, I expected to learn about lifestyle, exercise, and prevention. I did not walk in expecting hormone optimization to be a central pillar of healthy aging. I thought my own problem was simply stress and workload.

On paper, my testosterone numbers were not catastrophic. Yet when I completed the Aging Male Symptom Questionnaire, I was checking far too many boxes: low energy, reduced drive, decreased enthusiasm, more belly fat than I wanted, and a general sense that I was not the same man I had been.

When my testosterone was restored to youthful levels—roughly akin to the 25-year-old version of me rather than the 47-year-old version—the change was dramatic. Within three weeks, I felt like someone had restored an engine I did not know I had lost. I went from worrying about how I could possibly sustain my life-load to thinking, “I’ve got this.”

People think of testosterone as a “muscle drug,” but the organ with the greatest density of testosterone receptors is the brain. Hormone optimization changes how you feel, how you think, how motivated you are to move, and how deeply you engage with life. It does help with muscle, recovery, and body composition, but the most profound shift for me was psychological and energetic. It gave me the bandwidth to embrace the exercise prescription, nutritional changes, and movement strategy that are essential for long-term success.

 

What Most People Get Wrong About Testosterone

There are two big misconceptions I see over and over again.

The first is the idea that any use of testosterone is “juicing.” Juicing is when someone takes very high, super-physiologic doses to build abnormal amounts of muscle mass, well beyond what any healthy male would naturally produce. That is not what we do at Cenegenics. Our goal is to restore hormones to youthful, physiologic ranges so that the body functions as it did when recovery was better, energy was higher, and training felt natural.

The second misconception is that testosterone is a shortcut that replaces the need for movement, good sleep, and sound nutrition. In reality, testosterone is a force multiplier. It does not exercise for you, but it makes training feel possible again. It enhances recovery so that your workouts lead to progress rather than burnout. It gives you the mental drive to implement the lifestyle prescription instead of feeling overwhelmed by it.

When androgen levels are low, asking someone to change how they eat, train, and live can feel like asking them to climb a mountain with a broken leg. When testosterone returns to youthful levels, the same plan suddenly becomes feasible. That was my experience. It is the experience of many of my patients.

 

Why Physician Oversight Is Not Optional

Today, you can scroll social media, click a link, fill out a short questionnaire, and be placed on testosterone by an online clinic that has never seen you in person, barely checked your labs, and will not monitor you properly.

From a clinical standpoint, that should concern you.

I routinely meet patients who started with low-cost testosterone clinics or telehealth services and eventually realized something was not right. When they arrive in my practice and we look at their data, it is obvious they were never evaluated deeply or monitored adequately.

I see men who were prescribed testosterone without any documentation of genuine androgen deficiency. In many cases, no one bothered to differentiate between testicular failure and pituitary under-signaling because luteinizing hormone was never measured. I see men who were placed on doses that are far too high for their receptor sensitivity, yet their hematocrit, estradiol levels, and prostate markers were never followed. I see young men who have gained weight, started converting more testosterone to estrogen in their fat mass, and developed a vicious cycle of high estrogen, suppressed luteinizing hormone, and further testosterone decline—yet were simply handed more testosterone without addressing the root cause.

This is not good medicine. It is a product line.

Proper hormone optimization requires a physician who understands andrology, endocrine feedback loops, receptor sensitivity, and the difference between primary and secondary hypogonadism. It requires baseline and follow-up labs that include testosterone, estradiol, luteinizing hormone, detailed blood counts, metabolic markers, liver and kidney function, lipids, and prostate health. It requires someone who can interpret changes in those labs and adjust treatment accordingly.

In our Cenegenics practice, we do not simply write a prescription and hope for the best. We implement a structured plan and then watch how your biology responds. If hematocrit climbs, we know we may be pushing too hard or need to adjust dosage and scheduling. If estradiol rises, we anticipate and manage that. If someone’s physiology tells us they are more sensitive, we dial the dose back. This is nuance that strip-mall and telehealth clinics simply do not deliver.

 

 

 

Hormones as Part of a Larger Health Strategy

One of the most important differences between Cenegenics and low-tier hormone clinics is that testosterone is never the whole story for us. It is always part of an integrated healthspan strategy.

We pair hormone optimization with detailed lifestyle prescriptions that cover resistance training, cardiovascular conditioning, post-meal movement, sleep architecture, stress management, and targeted supplementation. We make sure that if you are going to train harder and feel better, you are also moving in a way that lowers cardiovascular risk, reduces visceral fat, improves insulin sensitivity, and protects cognitive function.

When you combine youthful hormone levels with a smart movement strategy and a nutrition plan that manages insulin and inflammation, you get a positive feedback loop. You feel better, so you train more. You train more effectively, so you sleep better and manage weight more easily. Your biomarkers improve. Seeing those improvements reinforces your commitment. Over time, you are not just preventing disease; you are building a higher-performing version of yourself.

That is the distinction between a disease model and a health model. In the ER, I learned to manage crises. At Cenegenics, I help patients avoid them.

Hormone optimization, done right, is not a gimmick or a shortcut. It is a powerful tool within a physician-led framework that is designed to protect healthspan, not just treat numbers.

Dr. Bob Ledda

Contributor: Dr. Bob Ledda, M.D., Cenegenics Physician Partner

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