Quick NavigationThe Gut MicrobiomeWhat is Epigenetics and how is it impacted through our DIET?How Can You Optimize Your Gut Microbiome by Unlocking Your Gene Mapping Through GI-Map Testing?What does the GI-MAP Test?Who Is a Good Candidate for GI-Map Testing?How Can the GI-Map Test Change Your Gut Microbiome?Next Steps to Discovering Your GI-Map
All Disease Begins in The Gut.
More than 2,000 years ago, Hippocrates understood “All Disease Begins in the Gut.”
Fast forward to 2020, healthcare is moving deeper into the space of personalized medicine and understanding how the genetic expression of our gut microbiome can elevate our health.
Our GUT MICROBIOME is the key to UNLOCKING PRISTINE HEALTH.
Bacteria, viruses, fungi and other microscopic living things are referred to as microorganisms, or microbes. Trillions of these microbes exist mainly inside your intestines and on your skin. There are more bacterial cells in your body than human cells. There are roughly 40 trillion bacterial cells in your body and only 30 trillion human cells. That means you are more bacteria than human. [1,2] In fact, there are up to 1,000 species of bacteria in the human gut microbiome weighing as much as 2–5 pounds (1–2 kg); each of them extremely important in determining your current and future health status. 
Recent studies have suggested the intestinal microbiome plays an important role in modulating risk of several chronic diseases, including:
It is now understood that diet plays a significant role in shaping the microbiome, with experiments showing that dietary alterations can induce large, temporary microbial shifts within 24 hrs.
The ecosystem of bacteria in the human gut operates dynamically, like any other human organ. In order to ensure stability in the face of constant disturbance, microbiota species are continuously interchangeable by means of the metabolites produced by the action of gene products contained in the gut bacteria. 
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. Epigenetic mechanisms include the covalent modifications of DNA and histones. 
Emerging evidence strongly suggests that consumption of dietary agents can alter normal epigenetic states as well as reverse abnormal gene activation or silencing.  Such diet-induced epigenetic changes may provide the key mechanistic link between diet-induced diseases and thus may serve as targets of intervention. 
Gene mapping is the sequential allocation of Loci to a relative position on a chromosome. Genetic maps are a necessary tool for mapping of disease genes or trait loci.  Gastrointestinal Microbial Assay Plus or the GI-MAP™ test [10,11,12,13] is an innovative clinical tool that measures gastrointestinal microbiota DNA from a single stool sample with state of the art, quantitative polymerase chain reaction (qPCR or real-time PCR) technology. Since the GI-MAP is a DNA-based test, results reflect the levels of pathogenic strains carrying the toxin genes, not the levels of any toxins that may be produced.
The GI-MAP was designed to detect microbes that may be disturbing normal microbial balance or contributing to illness as well as indicators such as:
The GI-MAP tests for PATHOGENS known to cause intestinal gastroenteritis:
GI-MAP Testing may be indicated if YOU suffer from or have a FAMILY HISTORY of one of the following:
The GI-MAP Test can pinpoint the pathogenic source and provide clinically proven therapeutic protocols to ameliorate the pathologies listed above promoting a healthy intestinal barrier or Gut Microbiome for optimal health.
Cenegenics New York now offers the GI-Map Testing. Our world class physicians create a personalized plan to help you feel 10+ years younger. You’ll be more energetic, lose weight, sleep better, have more libido, and think more clearly. Click below to schedule a free consultation with one of our physicians. It’s quick + easy.
About the Contributor
Dr. Cynthia BarrettPT, DPT, CSCS, CNS
Dr. Cynthia Barrett, PT, DPT, CSCS, CNS, is Founder and CEO of Wellness Couture, LLC, which provides targeted testing and evaluation as the foundation for the next level of health, nutrition and fitness based on each client’s unique microbiota and chemical makeup. Her success tailoring custom-made wellness programs for clients led her to partner with Cenegenics NYC, where she leads their Advanced Food and Nutrient Testing Program.
Dr. Barrett is a Certified Nutrition Specialist (CNS), focusing on the Gut Microbiome. Dr. Barrett has been featured in Business Insider and Women’s Day Magazines, providing expert nutrition insight. She holds a bachelor’s degree in Community Health Education from Hunter College and obtained her Doctorate in Physical Therapy (DPT) from New York University.
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 Qin J, Li R, Raes J, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464(7285):59–65. doi:10.1038/nature08821
 Integrative HMP (iHMP) Research Network Consortium. The Integrative Human Microbiome Project: dynamic analysis of microbiome-host omics profiles during periods of human health and disease. Cell Host Microbe. 2014;16(3):276–289. doi:10.1016/j.chom.2014.08.014
 Singh RK, Chang HW, Yan D, et al. Influence of diet on the gut microbiome and implications for human health. J Transl Med. 2017;15(1):73. Published 2017 Apr 8. doi:10.1186/s12967-017-1175-y
 Miro-Blanch J and Yanes O (2019) Epigenetic Regulation at the Interplay Between Gut Microbiota and Host Metabolism. Front. Genet. 10:638. doi: 10.3389/fgene.2019.00638
 Berdasco, M., Esteller, M. Clinical epigenetics: seizing opportunities for translation. Nat Rev Genet 20, 109–127 (2019) doi:10.1038/s41576-018-0074-2
 Hardy TM, Tollefsbol TO. Epigenetic diet: impact on the epigenome and cancer. Epigenomics. 2011;3(4):503–518. doi:10.2217/epi.11.71
 Ideraabdullah FY, Zeisel SH. Dietary Modulation of the Epigenome. Physiol Rev. 2018;98(2):667–695. doi:10.1152/physrev.00010.2017
 Kelly L. Williams, in Encyclopedia of Bioinformatics and Computational Biology, 2019
 Angol DC, Ocama P, Ayazika Kirabo T, Okeng A, Najjingo I, Bwanga F. Helicobacter pylori from Peptic Ulcer Patients in Uganda Is Highly Resistant to Clarithromycin and Fluoroquinolones: Results of the GenoType HelicoDR Test Directly Applied on Stool. BioMed research international. 2017;2017:5430723.
 Segata N, Haake SK, Mannon P, et al. Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples. Genome Biol. 2012;13(6):R42.
 Fraser SL. Enterococcal infections. 2017; https://emedicine.medscape.com/article/216993-overview#a5. Accessed Jul 4, 2018.
 Walsham NE, Sherwood RA. Fecal calprotectin in inflammatory bowel disease. Clinical and experimental gastroenterology. 2016;9:21-29. PHOTO CREDIT ***Moya A, Ferrer M. Functional redundancy-induced stability of gut microbiota subjected to disturbance. Trends Microbiol. 2016. doi:10.1016/j.tim.2016.02.002.
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